Pediatric Eye Disease Investigator Group (PEDIG)

Protocol: NLD3 - A Randomized Trial Comparing Immediate Probing in an Office Setting with Deferred Probing in a Facility Setting for Treatment of Nasolacrimal Duct Obstruction in Children 6 to <10 Months Old
Status: Closed
Start Date: 10/29/2008
End Date: 08/31/2011
Clinical Trial ID: NCT00780741
Public Dataset:  Download


A Randomized Trial Comparing Immediate Probing in an Office Setting with Deferred Probing in a Facility Setting for Treatment of Nasolacrimal Duct Obstruction in Children 6 to <10 Months Old

Protocol

Objectives:

  • Primary objective:
    • To determine the cost-effectiveness of treating NLDO using immediate office probing compared with deferred probing in a facility setting. As part of the primary objective, the study will determine the proportion of eyes experiencing spontaneous resolution among subjects randomized to the deferred probing group.
  • Secondary objectives:
    • To determine the success proportion for eyes undergoing immediate office probing as an initial procedure.
    • To determine the success proportion for eyes undergoing deferred facility probing as an initial procedure.

Published Manuscripts:

  1. Pediatric Eye Disease Investigator Group. Resolution of Congenital Nasolacrimal Duct Obstruction With Nonsurgical Management. Arch Ophthalmol. 2012;130(6):730-734
  2. Pediatric Eye Disease Investigator Group. A randomized trial comparing the cost-effectiveness of 2 approaches for treating unilateral nasolacrimal duct obstruction. Arch Ophthalmol 2012;130:1525-33
  3. Lee KA, Chandler DL, Repka MX, Melia M, Beck RW, Summers CG, Frick KD, Foster NC, Kraker RT, Atkinson S, Avallone JM, on behalf of PEDIG. A Comparison of Treatment Approaches for Bilateral Congenital Nasolacrimal Duct Obstruction. Am J Ophthalmol Nov 2013; 156(5):1045-1050
  4. Miller AM, Chandler DL, Repka MX, et al. Office probing for treatment of nasolacrimal duct obstruction in infants. J AAPOS. Feb 2014;18(1):26-30.

 



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