An Observational Study of Infantile, Acquired Non-accommodative, and Acquired Partially-accommodative Esotropia

Protocol

Study Objective:
To determine the proportion of patients with angle instability in infantile, acquired non-accommodative, and acquired partially-accommodative esotropia
 

Summary of Results:
One hundred twenty one (121) subjects were enrolled with infantile esotropia, 112 with non-accommodative esotropia, and 61 with partially-accommodative esotropia.

• Infantile Esotropia
  Among subjects with infantile esotropia, 46% had ocular alignment classified as unstable (95% confidence interval (CI) = 33 to 59%), 20% as stable (95% CI = 11 to 33%), and 34% as uncertain (95% CI = 22 to 47%).
  
• Acquired Non-accommodative Esotropia
  Among subjects with acquired non-accommodative esotropia, 22% had ocular alignment classified as unstable (95% confidence interval (CI) = 12 to 34%), 37% as stable (95% CI = 25 to 50%), and 42% as uncertain (95% CI = 29 to 55%).
  
• Acquired Partially-accommodative Esotropia
  Among subjects with acquired partially-accommodative esotropia, 15% had ocular alignment classified as unstable (95% CI = 6 to 29%), 39% as stable (95% CI = 24 to 56%), and 46% as uncertain (95% CI = 31 to 63%).

Conclusion:
Ocular alignment instability is common for children with infantile, non-accommodative, and partially-accommodative esotropia.
 

Publications:

1. Pediatric Eye Disease Investigator Group. Instability of Ocular Alignment in Childhood Esotropia. Ophthalmology 2008;115(12):2266-74.
2. Pediatric Eye Disease Investigator Group. Interobserver Reliability of the Prism and Alternate Cover Test in Children With Esotropia. Arch Ophthalmol 2009;127(1):59-65.