Pediatric Eye Disease Investigator Group (PEDIG)

Protocol: ATS15 - Increasing Patching for Amblyopia Study
Status: Closed
Start Date: 08/05/2009
End Date: 03/01/2013
Clinical Trial ID: NCT00945100
Public Dataset:  Download


Increasing Patching for Amblyopia Study

Protocol

Objective:
This study is designed to evaluate the effectiveness of increasing prescribed patching treatment from 2 to 6 daily hours after visual acuity has stabilized with initial treatment and amblyopia is still present. Children ages 3 to <8 years with visual acuity of 20/50 to 20/400 in the amblyopic eye will be enrolled in a run-in phase with 2 hours daily patching until no improvement, followed by randomization of eligible patients to patching 2 hours daily versus an average of 6 hours daily (42 hours per week). The primary objective is to determine if increasing patching dosage will improve visual acuity in patients with amblyopia still present after visual acuity has stabilized with initial treatment.


Publications:
  1. Pediatric Eye Disease Investigator Group. A randomized trial of increasing patching for amblyopia. Ophthalmology 2013 Nov;120(11):2270-7. Epub 2013 Jun 4
  2. Wallace DK, Lazar EL, Crouch ER, III, Hoover DL, Tamkins SM, on behalf of Pediatric Eye Disease Investigator Group. Time course and predictors of amblyopia improvement with 2 hours of daily patching. JAMA Ophthalmol 2015;133:606-9.

 



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