Pediatric Eye Disease Investigator Group (PEDIG)

Protocol: NLD2 - A Prospective Study of Surgical Procedures for the Treatment of Persistent Nasolacrimal Duct Obstruction in Children Less Than Four Years Old
Status: Closed
Start Date: 02/01/2005
End Date: 02/22/2008
Clinical Trial ID: NCT00315315
Public Dataset:  Download


A Prospective Study of Surgical Procedures for the Treatment of Persistent Nasolacrimal Duct Obstruction in Children Less Than Four Years Old

Protocol

 

Study Objectives: 

  • The primary objective was to compare the success proportions of balloon catheter dilation and nasolacrimal intubation for the treatment of persistent nasolacrimal duct obstruction (NLDO). 
  • A secondary objective was to report the success proportion of repeat probing for the treatment of persistent NLDO.
Summary of Results:
Ninety five (95) eyes of 73 subjects underwent balloon catheter dilation, 104 eyes of 90 subjects underwent nasolacrimal intubation, and 23 eyes in 20 subjects underwent repeat probing.

Treatment success was reported in 77% (95% CI = 65% to 85%) of eyes in the balloon group compared with 84% (95% CI = 74% to 91%) of eyes in the intubation group (risk ratio for success for intubation vs. balloon = 1.08, 95% CI = 0.95 to 1.22).

Treatment success was reported 56% [95% confidence interval = 33% to 76%]) of eyes in the repeat probing group.
 

Conclusions:
Balloon catheter dilation and nasolacrimal duct intubation each alleviate the clinical signs of persistent NLDO in a similar proportion of patients (about 80%).

Repeat probing is a successful treatment for persistent NLDO about half the time.

 

Publications:

  1. Pediatric Eye Disease Investigator Group. Balloon catheter dilation and nasolacrimal duct intubation for treatment of nasolacrimal duct obstruction after failed probing. Arch Ophthalmol 2009;127(5):1-7.
  2. Pediatric Eye Disease Investigator Group. Repeat probing for treatment of persistent nasolacrimal duct obstruction. J AAPOS 2009;13(3):306-7.

 



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